Is there a way to set of a formula for this:

In the fifth column, calculate ?V (the change in volume, which is Vn+1– Vn). For example, the change in volume from the first data point (V1) to the second data point (V2) is ?V = V2 – V1.

In Excel columns are letters and rows are numbers

Column 5 is column E

Assume you start with row 3
Let cell E2 = Vstart

Set V1 as column C
Set V2 as column D
The formula in column 5 will be
V2 – V1
or formula
=D3-C3+E2

Now this will give you the difference. But you are asking for the delta change. And you are not including enough data to write a calc formula.

But a total change is
V1V2
Vstart1
1232
2343
3454
4565

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